Journal: medRxiv

Article Title: The angiotensin type 2 receptor agonist C21 restores respiratory function in COVID19 - a double-blind, randomized, placebo-controlled Phase 2 trial

doi: 10.1101/2021.01.26.21250511

Figure Lengend Snippet: Daily estimates of the proportion of patients in need for supplemental oxygen therapy. The left panel shows the total intention to treat population (C21 N=51, placebo N=55). The upper right panel shows patients in need for supplemental oxygen on the day of randomization (C21 N=37, placebo N=39), and the lower right panel shows patients not in need for oxygen on the day of randomization (C21 N=14, placebo N=16).

Article Snippet: In conclusion, C21 on top of standard of care, including glucocorticoids and remdesivir, significantly improved respiratory function reflected by a reduced need for supplemental oxygen in hospitalized COVID-19 patients.

Techniques:

Journal: Cell reports

Article Title: AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences

doi: 10.1016/j.celrep.2023.112903

Figure Lengend Snippet: KEY RESOURCES TABLE

Article Snippet: ​ REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Monoclonal Rabbbit anti-TTR (prealbumin) AbCam Cat # ab75815; RRID:AB_1310604 Monoclonal Rabbit anti-Insulin Cell Signaling Cat # 3014; RRID:AB_2126503 Polyclonal Rabbit anti-mCherry Rockland Cat # 600-401-P16; RRID:AB_2614470 Monoclonal Rabbit anti- p -Akt (Ser473) Cell Signaling Cat # 4060; RRID:AB_2315049 Monoclonal Mouse anti-Alpha1 Na+/K+ ATPase AbCam Cat # ab7671; RRID:AB_306023 Bacterial and virus strains AAV5-CMV-CRE Vector Biolabs Cat # 7012 AAV5-CMV-GFP Vector Biolabs Cat # 7006 AAV5-CMV-Ins2 Vector Biolabs Cat # AAV-262269 AAV5-CMV-GCaMP6f Vector Biolabs Built to order AAV5-TTR-hM3Dq-mCherry Vector Biolabs Built to order AAV5-CMV-Psck1 Vector Biolabs Cat # AAV-268239 AAV5-CMV-Pcsk2 Vector Biolabs Cat # AAV-268242 Chemicals, peptides, and recombinant proteins Compound 21 TOCRIS Cat # 5548 Critical commercial assays PicoPure RNA Isolation Kit ThermoFisher Cat # KIT0204 Ultra Sensitive Insulin ELISA Kit CrystalChem Cat # 90080 Deposited data Raw and analyzed data of RNA-seq This paper GEO: GSE218188 Experimental models: Cell lines iPS(IMR90)-4 WiCell WISCi004-B Experimental models: Organisms/strains C57BL/6J The Jackson Laboratory Strain # 000664 Ai14 The Jackson Laboratory Strain #007914 Ins1 −/− Ins2 fl/fl This paper N/A Software and algorithms ImageJ NIH https://imagej.nih.gov/ij/ GraphPad Prism GraphPad https://graphpad.com R R Foundation for Statistical Computing https://www.r-project.org Other Normal chow diet Dyets Inc Cat# 101845 High fat/high sugar diet Dyets Inc Cat# 103806 Open in a separate window KEY RESOURCES TABLE.

Techniques: Virus, Plasmid Preparation, Recombinant, Isolation, Enzyme-linked Immunosorbent Assay, Software

Journal: Russian Journal of Physical Chemistry

Article Title: Effect of Et2Zn on Binding Spike Protein of SARS-Cov-2 and ACE2 from Cell Membrane

doi: 10.1134/S0036024423050163

Figure Lengend Snippet: Donor–acceptor results, E2 (resonance energy), occupancy, hybrid for RBD/Gly-Phe/hAP and RBD/Cys-Glu/hAPN

Article Snippet: RBD/Cys-Glu/hAPN , 0.8923 , BD (1) Zn9–C21 s 1 p 0.43 d 0.18 , BD (1) Zn9–C2 (Donor) BD*(1) C21–O22 (Acceptor) , 0.86.

Techniques:

Journal: Foods

Article Title: Effect of Near-Freezing Storage Combined with High-Voltage Electric Fields on the Freshness of Large Yellow Croaker

doi: 10.3390/foods13182877

Figure Lengend Snippet: The main reagents in the experiment.

Article Snippet: Total volatile basic nitrogen , Magnesium oxide (MgO) Boric acid (H 3 BO 3 ) Hydrochloric acid (HCl) Methyl red indicator (C 15 H 15 N 3 O 2 ) Bromocresol green indicator (C 21 H 14 Br 4 O 5 S) , Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China).

Techniques: Sterility, Saline

Journal: Toxins

Article Title: Host Genotype and Weather Effects on Fusarium Head Blight Severity and Mycotoxin Load in Spring Barley

doi: 10.3390/toxins14020125

Figure Lengend Snippet: Genotype ranking according to detected Fusarium toxin contents in mature barley heads after bruised grain inoculation in the seasons 2018 to 2020. The heat map represents scored mean ranks according to detected contents of DON, NIV, DON3G, 3ADON, enniatins A, A1, B and B1 in mature barley heads in inoculated sub plots. Mean ranks of individual genotypes and the respective standard error of the mean are presented in the grey shaded box. Low ranks indicate high FHB resistance; high ranks indicate low FHB resistance. Error bars indicate standard error of the mean.

Article Snippet: Unlabelled reference compounds (deoxynivalenol-3-glucoside (D3G), 15-acetyl-deoxynivalenol (15-ADON), T2-toxin) and some labelled standards ( 13 [C 15 ]-DON, 13 [C 17 ]-3-ADON, 13 [C 22 ]-HT2-toxin and 13 [C 21 ]-D3G) were purchased from Biopure (Tulln, Austria).

Techniques: